Soil-transmitted helminth infections are caused by different parasitic worms and 24% population in the world are suffered from it, especially people from poot communities. Type 2 immune response is elicited when encountered parasitic pathogen to facilitate worm clearance and restrain worm reproductivity. In the immune regulation, nuclear receptor is master regulator via sensing hormone or endocrine-like component from the endogeny or external environment. Liver X receptor is a nuclear receptor playing a crucial role in cholesterol metabolism. It can be activated by endogenous oxysterols or intake of natural ligands such as phytosterols derived from plants or fungi, which may affect the immune system. My project aims to find the impact of LXR activation on anti-helminth immune response.