NING HE
PHD STUDENT
Intestinal stem cell (ISC) niche refers to a microenvironment, within a specific anatomic location called intestinal crypts, which interacts with ISCs to regulate their self-renewal and determine their cell fates. ISCs maintain the intestinal homeostasis but at the same time remain highly heterogeneous in the healthy condition and various diseases. My research directions are aimed at mapping the crypt-associated niche (CAN) heterogeneity in the normal condition and different intestinal disease models based on integrating single cell RNA sequencing with spatial transcriptomics, and finally defining how some potential signatures work in CANs by combining the organoid culture with gene-edited mice, etc.
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