BK



CONTACT INFORMATION

BIANCA KERN

PHD STUDENT

The gastrointestinal tract is exposed daily to environmental challenges such as pollutants and dietary components that ultimately affect mucosal immunity at the intestinal barrier. During my undergraduate thesis, I worked on establishing a zebrafish-based in vivo model to study intestinal damage and regeneration with its potential use for compound screenings of possible modulators of intestinal recovery. As part of my PhD project, I am currently investigating the effects of environmental factors on intestinal homeostasis. In particular, I aim to characterise the spatiotemporal transcriptomic programs associated with tertiary lymphoid structure-mediated anti-tumour immunity in colorectal cancer and how this is modulated by dietary cholesterol metabolites. In addition, I am interested in elucidating the mechanisms by which environmental pollutants (e.g. PFAS) exacerbates intestinal inflammation and whether they influence the processes of mucosal healing following intestinal injury.

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