The gastrointestinal tract is exposed daily to environmental challenges such as pollutants and dietary components that ultimately affect mucosal immunity at the intestinal barrier. During my undergraduate thesis, I worked on establishing a zebrafish-based in vivo model to study intestinal damage and regeneration with its potential use for compound screenings of possible modulators of intestinal recovery. As part of my PhD project, I am currently investigating the effects of environmental factors on intestinal homeostasis. In particular, I aim to characterise the spatiotemporal transcriptomic programs associated with tertiary lymphoid structure-mediated anti-tumour immunity in colorectal cancer and how this is modulated by dietary cholesterol metabolites. In addition, I am interested in elucidating the mechanisms by which environmental pollutants (e.g. PFAS) exacerbates intestinal inflammation and whether they influence the processes of mucosal healing following intestinal injury.